{"id":3322,"date":"2025-01-23T10:41:48","date_gmt":"2025-01-23T10:41:48","guid":{"rendered":"https:\/\/www.sus-mirri.it\/2025\/01\/a-guide-to-the-use-of-bioassays-in-exploration-of-natural-resources\/"},"modified":"2025-01-23T10:51:43","modified_gmt":"2025-01-23T10:51:43","slug":"a-guide-to-the-use-of-bioassays-in-exploration-of-natural-resources","status":"publish","type":"post","link":"https:\/\/www.sus-mirri.it\/it\/2025\/01\/a-guide-to-the-use-of-bioassays-in-exploration-of-natural-resources\/","title":{"rendered":"A guide to the use of bioassays in exploration of natural resources."},"content":{"rendered":"\n<p>Saboti\u010d J, Bayram E, Ezra D, Gaud\u00eancio SP, Haznedaro\u011flu BZ, Jane\u017e N, Ktari L, Luganini A, Mandalakis M, Safarik I, Simes D, Strode E, Toru\u0144ska-Sitarz A, Varamogianni-Mamatsi D, Varese GC, Vasquez MI. 2024 A guide to the use of bioassays in exploration of natural resources.<em> Biotechnology Advances<\/em> Vol. 5:71:108307 36 <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0734975024000016?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0734975024000016?via%3Dihub<\/a><\/p>\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n<p>Bioassays are the main tool to decipher <a href=\"https:\/\/www.sciencedirect.com\/topics\/biochemistry-genetics-and-molecular-biology\/biological-activity\">bioactivities<\/a> from <a href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/natural-resources\">natural resources<\/a> thus their selection and quality are critical for optimal bioprospecting. They are used both in the early stages of compounds isolation\/purification\/identification, and in later stages to evaluate their safety and efficacy. In this review, we provide a comprehensive overview of the most common bioassays used in the discovery and development of new <a href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/bioactive-compound\">bioactive compounds<\/a> with a focus on marine bioresources. We present a comprehensive list of practical considerations for selecting appropriate bioassays and discuss in detail the bioassays typically used to explore antimicrobial, antibiofilm, cytotoxic, antiviral, antioxidant, and anti-ageing potential. The concept of <a href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/quality-control\">quality control<\/a> and bioassay validation are introduced, followed by safety considerations, which are critical to advancing bioactive compounds to a higher stage of development. We conclude by providing an application-oriented view focused on the development of pharmaceuticals, food supplements, and cosmetics, the industrial pipelines where currently known marine <a href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/natural-product\">natural products<\/a> hold most potential. We highlight the importance of gaining reliable bioassay results, as these serve as a starting point for application-based development and further testing, as well as for consideration by regulatory authorities.      <\/p>\n\n<p>Continue reading at: <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0734975024000016?via%3Dihub\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0734975024000016?via%3Dihub<\/a><\/p>\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Saboti\u010d J, Bayram E, Ezra D, Gaud\u00eancio SP, Haznedaro\u011flu BZ, Jane\u017e N, Ktari L, Luganini A, Mandalakis M, Safarik I, Simes D, Strode E, Toru\u0144ska-Sitarz A, Varamogianni-Mamatsi D, Varese GC, Vasquez MI. 2024 A guide to the use of bioassays in exploration of natural resources. Biotechnology Advances Vol. 5:71:108307 36 https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0734975024000016?via%3Dihub Abstract Bioassays are the [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":3320,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[58],"tags":[108,64],"class_list":["post-3322","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-it","tag-pubblications-it","tag-sus-mirri-it"],"uagb_featured_image_src":{"full":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6.png",1080,1080,false],"thumbnail":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-150x150.png",150,150,true],"medium":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-300x300.png",300,300,true],"medium_large":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-768x768.png",768,768,true],"large":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-1024x1024.png",1024,1024,true],"1536x1536":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6.png",1080,1080,false],"2048x2048":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6.png",1080,1080,false],"blade-grve-large-rect-horizontal":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-1080x658.png",1080,658,true],"blade-grve-small-square":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-600x600.png",600,600,true],"blade-grve-small-rect-horizontal":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-800x600.png",800,600,true],"blade-grve-small-rect-horizontal-wide":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-800x450.png",800,450,true],"blade-grve-small-rect-vertical":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-600x800.png",600,800,true],"blade-grve-medium-rect-vertical":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6-560x1080.png",560,1080,true],"blade-grve-medium-square":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6.png",1080,1080,false],"blade-grve-fullscreen":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/01\/SUS-MIRRI-6.png",1080,1080,false]},"uagb_author_info":{"display_name":"Maria Gullo","author_link":"https:\/\/www.sus-mirri.it\/it\/author\/maria-gullo\/"},"uagb_comment_info":0,"uagb_excerpt":"Saboti\u010d J, Bayram E, Ezra D, Gaud\u00eancio SP, Haznedaro\u011flu BZ, Jane\u017e N, Ktari L, Luganini A, Mandalakis M, Safarik I, Simes D, Strode E, Toru\u0144ska-Sitarz A, Varamogianni-Mamatsi D, Varese GC, Vasquez MI. 2024 A guide to the use of bioassays in exploration of natural resources. Biotechnology Advances Vol. 5:71:108307 36 https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0734975024000016?via%3Dihub Abstract Bioassays are the&hellip;","_links":{"self":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts\/3322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/comments?post=3322"}],"version-history":[{"count":1,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts\/3322\/revisions"}],"predecessor-version":[{"id":3323,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts\/3322\/revisions\/3323"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/media\/3320"}],"wp:attachment":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/media?parent=3322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/categories?post=3322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/tags?post=3322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}