{"id":3370,"date":"2025-02-03T16:35:48","date_gmt":"2025-02-03T16:35:48","guid":{"rendered":"https:\/\/www.sus-mirri.it\/2025\/02\/co-cultivation-of-komagataeibacter-sp-and-lacticaseibacillus-sp-strains-to-produce-bacterial-nanocellulose-hyaluronic-acid-nanocomposite-membranes-for-skin-wound-healing-applications\/"},"modified":"2025-02-03T16:35:48","modified_gmt":"2025-02-03T16:35:48","slug":"co-cultivation-of-komagataeibacter-sp-and-lacticaseibacillus-sp-strains-to-produce-bacterial-nanocellulose-hyaluronic-acid-nanocomposite-membranes-for-skin-wound-healing-applications","status":"publish","type":"post","link":"https:\/\/www.sus-mirri.it\/it\/2025\/02\/co-cultivation-of-komagataeibacter-sp-and-lacticaseibacillus-sp-strains-to-produce-bacterial-nanocellulose-hyaluronic-acid-nanocomposite-membranes-for-skin-wound-healing-applications\/","title":{"rendered":"Co-cultivation of Komagataeibacter sp. and Lacticaseibacillus sp. strains to produce bacterial nanocellulose-hyaluronic acid nanocomposite membranes for skin wound healing applications"},"content":{"rendered":"\n<p>Brugnoli M, Carvalho JPF, Arena MP, Oliveira H, Vilela C, Freire CSR, Gullo M. 2025 Co-cultivation of Komagataeibacter sp. and Lacticaseibacillus sp. strains to produce bacterial nanocellulose-hyaluronic acid nanocomposite membranes for skin wound healing applications International Journal of Biological Macromolecules 299: 140208\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39848389\/\">10.1016\/j.ijbiomac.2025.140208<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>Inspired by natural microbial cooperation, a co-culture approach was used to synthesize bacterial nanocellulose (BNC)-based nanocomposites for potential wound healing applications. By co-culturing either Komagataeibacter xylinus (K1G4) or the never tested strain K. rhaeticus (K2G46) with the hyaluronic acid (HA)-producer Lacticaseibacillus casei UMCC 2535, two BNC-HA nanocomposites were obtained (C1-K1 and C2-K2). The membranes showed a HA content of 0.49 \u00b1 0.05 mg (C1-K1) and 1.40 \u00b1 0.07 mg (C2-K2), and both revealing a nearly complete release of HA after 1 h in PBS. Compared to pure BNC membranes, the nanocomposites showed enhanced properties, including higher crystallinity (K1G4 = 84.6 %; K2G46 = 76.5 %; C1-K1 = 89.1 %; C2-K2 = 88.1 %), and Young&#8217;s modulus (K1G4 = 3.38 \u00b1 0.56 GPa; K2G46 = 2.22 \u00b1 0.65 GPa; C1-K1 = 10.00 \u00b1 1.32 GPa; C2-K2 = 7.90 \u00b1 1.54 GPa). Additionally, both BNC-HA membranes exhibited increased moisture uptake (K1G4 = 9.06 \u00b1 0.47 %; K2G46 = 9.27 \u00b1 1.33 %; C1-K1 = 13.65 \u00b1 0.53 %; C2-K2 = 16.26 \u00b1 1.05 %) and water absorption (K1G4 = 82.18 \u00b1 5.25 %; K2G46 = 86.54 \u00b1 7.86 %; C1-K1 = 160.04 \u00b1 9.33 %; C2-K2 = 144.42 \u00b1 13.86 %) capacity. Moreover, they were non-cytotoxic towards human keratinocyte (HaCaT) cells, with &gt;90 % cell viability for up to 72 h. The in vitro scratch assays showed a complete wound closure within 48 h for cells exposed to BNC-HA membranes. These findings underscore the potential of co-culturing system to develop BNC-HA nanocomposites for wound healing applications.<\/p>\n\n\n\n<p>Read more at: <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39848389\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/39848389\/<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Brugnoli M, Carvalho JPF, Arena MP, Oliveira H, Vilela C, Freire CSR, Gullo M. 2025 Co-cultivation of Komagataeibacter sp. and Lacticaseibacillus sp. strains to produce bacterial nanocellulose-hyaluronic acid nanocomposite membranes for skin wound healing applications International Journal of Biological Macromolecules 299: 140208\u00a010.1016\/j.ijbiomac.2025.140208 Abstract Inspired by natural microbial cooperation, a co-culture approach was used to synthesize [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":3357,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_uag_custom_page_level_css":"","footnotes":""},"categories":[58],"tags":[71,108,64],"class_list":["post-3370","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-it","tag-mirri-it","tag-pubblications-it","tag-sus-mirri-it"],"uagb_featured_image_src":{"full":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1.png",1080,1080,false],"thumbnail":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-150x150.png",150,150,true],"medium":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-300x300.png",300,300,true],"medium_large":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-768x768.png",768,768,true],"large":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-1024x1024.png",1024,1024,true],"1536x1536":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1.png",1080,1080,false],"2048x2048":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1.png",1080,1080,false],"blade-grve-large-rect-horizontal":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-1080x658.png",1080,658,true],"blade-grve-small-square":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-600x600.png",600,600,true],"blade-grve-small-rect-horizontal":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-800x600.png",800,600,true],"blade-grve-small-rect-horizontal-wide":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-800x450.png",800,450,true],"blade-grve-small-rect-vertical":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-600x800.png",600,800,true],"blade-grve-medium-rect-vertical":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1-560x1080.png",560,1080,true],"blade-grve-medium-square":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1.png",1080,1080,false],"blade-grve-fullscreen":["https:\/\/www.sus-mirri.it\/wp-content\/uploads\/2025\/02\/SUS-MIRRI-1-1.png",1080,1080,false]},"uagb_author_info":{"display_name":"Maria Gullo","author_link":"https:\/\/www.sus-mirri.it\/it\/author\/maria-gullo\/"},"uagb_comment_info":0,"uagb_excerpt":"Brugnoli M, Carvalho JPF, Arena MP, Oliveira H, Vilela C, Freire CSR, Gullo M. 2025 Co-cultivation of Komagataeibacter sp. and Lacticaseibacillus sp. strains to produce bacterial nanocellulose-hyaluronic acid nanocomposite membranes for skin wound healing applications International Journal of Biological Macromolecules 299: 140208\u00a010.1016\/j.ijbiomac.2025.140208 Abstract Inspired by natural microbial cooperation, a co-culture approach was used to synthesize&hellip;","_links":{"self":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts\/3370","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/comments?post=3370"}],"version-history":[{"count":0,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/posts\/3370\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/media\/3357"}],"wp:attachment":[{"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/media?parent=3370"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/categories?post=3370"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sus-mirri.it\/it\/wp-json\/wp\/v2\/tags?post=3370"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}